The boys were aged 13 and 14 - Four other children aged from 11 to seven months remain in hospital.
A man, 37, and a woman, 34, have been arrested on suspicion of murder after "reports of concerns for safety" at a house in Sheffield, UK, today.
Two boys, aged 13 and 14, died after being taken to hospital with the other children - aged 11, 10, three and seven months.
The others remain in hospital, their condition has not been revealed.
Police in Sheffield are calling the deaths a 'serious incident' and are still trying to work out how the boys died.