It's expected to be bigger than the first.
Hundreds of trucks brought the capital to a standstill last month over rising fuel prices.
The average driver can expect to pay around €1.74 a litre for petrol, or around €163 for diesel.
Last year, those prices were around €1.25 and €1.17 respectively.
The newly-formed Irish Truckers and Haulage Association Against Fuel Prices is organising another protest.
It'll be for 24-hours and begin from early Monday morning.
Convoys of trucks will travel from Cork, Galway, Donegal, Wexford and Monaghan to Dublin.
On their Facebook page, they've said they're expecting "massive" numbers of trucks, tractors, busses, cars & vans and members of the public.
Representatives from the retail sector are asking those taking part to consider the impact it'll have on retail outlets in the Capital.
Richard Guiney of Dublin Town, which represents traders in the Capital, said this is coming at a very difficult time for businesses in Dublin.
He's saying they need to consider the impact it'll have on retail, with trade already down.
The association has been giving details of meeting points as well - with the times each area and convoy is expected to leave certain points.
Farmers are expected to be joining the protest as well.