The incident happened in the Bunboggan area of Athboy
Gardai in Meath are currently at the scene of a serious road crash in Athboy.
It happened in the Bunboggan area shortly before 2 o'clock this morning.
A male passenger in the car involved was taken to Midland Regional Hospital, Mullingar, for treatment of serious injuries.
The male driver of the car was taken to Our Lady of Lourdes Hospital, Drogheda, with non-life threatening injuries.
The road is currently closed in order for a technical examination to be conducted.
Local diversions are in place.