Jackson signed for the club last month.
Diageo has cancelled its sponsorship of London Irish Rugby Club over concerns at the signing of Paddy Jackson.
The drinks company say signing the former Ulster and Ireland out half is not consistent with their values.
In a one line statement Diageo confirmed the end of their relationship with London Irish after a meeting to express their concerns.
The global drinks giant makes some of the worlds biggest brands including Guinness and are now the second sponsor to cancel their contract with the club.
Cash Converters ended its sponsorship in recent weeks. However, the club argued the decision to end the deal was not specifically related to Jackson's signing.
27-year-old Jackson was acquitted of rape after a lengthy trial at Belfast Crown Court last year.
He was signed last month after one season with the French side Perpignan.