It's the question people have been asking for years - you're heading for a big night out with your mates but you're afraid of the pain that awaits you the morning after.
Several rememdies have been tried an tested over the years (although abstinence is always the best) to prevent a hangover, to varying degrees of success.
But new research suggests taking a probiotic before a big night out could help stave off the worst effects of a hangover.
Experts from the Chinese Academy of Science found an enzyme contained in the probiotic may also stop people from getting drunk in the first place.
Studies carried out in mice found the pill which was packed with 'good' gut bacteria, made them absorb less alcohol and could reduce damage done to the liver and intestines from drinking.