Last-ditch talks at the Workplace Relations Commission aimed at preventing next week's nurses' strike have ended with no settlement.
Next Wednesday’s planned 24-hour strike will now go ahead.
15,000 patients are likely to be impacted. There will be no out-patient appointments or elective surgeries.
Hospitals are currently in the process of contacting those patients who will be affected.
The Irish Nurses and Midwives Organisation has called on Taoiseach Leo Varadkar to intervene in the dispute.
Nurses had held three days of talks with the HSE at the Workplace Relations Commission.
Five further dates next month could also be hit with strike action by the 40,000 nurses who are striking.
Nurses could again hit the picket-lines, on February 5th, 7th, 12th, 13th and 14th.