He temporarily stepped back from the role in July.
The Department of Health's Chief Medical Officer Dr Tony Holohan will return to his post next week.
He stepped back from the role in July because his wife was receiving palliative care, with Dr Ronan Glynn filling in.
Dr Holohan had become a well-known figure during the early stages of the Covid-19 pandemic. He recommended strict measures to tackle the virus, including the national lockdown.
Health Minister Stephen Donnelly says his return is very positive news.